KMID : 0816120120150010013
|
|
Korean Journal of Pediatric Gastroenterolology and Nutrition 2012 Volume.15 No. 1 p.13 ~ p.18
|
|
Biological Therapy for Inflammatory Bowel Disease in Children
|
|
Na So-Young
Shim Jung-Ok
|
|
Abstract
|
|
|
The pathogenesis of inflammatory bowel diseases is not very well understood; it is currently thought to be caused by the interaction between genetic factors, environmental factors, intestinal microbes, and immune factors. Biological agents such as anti-tumor necrosis factor (anti-TNF) are widely being used as therapeutic agents. Infliximab, a chimeric monoclonal IgG1 antibody against tumor necrosis factor, has been demonstrated to have an effect in the induction and maintenance of remission in Crohn¡¯s disease in children. The effects of biological agents, typified by anti-TNFs, in inflammatory bowel disease in children; the recent concern on the administration of biological agents in combination with immunomodulators; and ¡¯Top-down¡¯ therapy are some of the topics covered in this review.
|
|
KEYWORD
|
|
Inflammatory bowel disease, Infliximab, Children
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|